that matters to you. advanced squamous cell carcinoma of the head and neck. 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. 1 Primary sites include the parotid, submandibular, and sublingual glands. The response rate and the survival rates achieved with this treatment regimen are particularly noteworthy, especially considering the advanced stage of the patients treated. The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. concurrent ifosfamide was 10.2 g/m2. Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). You can change your cookie settings through your browser. Biochemistry, Genetics and Molecular Biology. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. Enjoy affordable access to 1995 Feb;13(2):452-8.) Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. vs concurrent chemoradiotherapy with TPF in patients with locally . All DeepDyve websites use cookies to improve your online experience. Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). vs 1.6 yrs. However, PCI was delivered more frequently for the sequential group. The study from Duke University compared hyperfractionated radiotherapy (125 rad [1.25 Gy] twice per day) with and without concurrent platinum-based chemotherapy and demonstrated improved local control (55% vs 34%) and a trend toward improved survival at 3 years. What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? Search (AM J Otolaryngol 2000;21:306-311. However, around one-third of the patients cannot complete cisplatin because of toxicity. Komaki R, Seiferheld W, Curran W, et al. Journal Article. 64 - Segawa Y, Kiura K, Takigawa N, et al. If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. Median follow-up was 23.5 months (2-79 months). We use cookies to help provide and enhance our service and tailor content and ads. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The hazard of accelerated tumor clonogen repopulation during radiotherapy, Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with nonsmall cell lung cancer (NSCLC), Schuster-Uitterhoeve, ALJ; Hulshof, MCCM; Gonzales, DG; Koolen, M; Sminia, P, Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): long-term results, Graham, MV; Pajak, TE; Herskovic, AM; Emami, B; Perez, CA, High-dose, hyperfractionated, accelerated radiotherapy using a concurrent boost for the treatment of nonsmall cell lung cancer: unusual toxicity and promising early results, Concomitant boost radiation therapy for inoperable non-small cell lung cancer: Preliminary report of a prospective randomized study, Paclitaxel as a radiation sensitizer in non-small cell lung cancer, Preliminary analysis of a phase II study of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small cell lung cancer, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC), Nonparametric estimation from incomplete observations, N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the Radiation Therapy Oncology Group, Induction cisplatin/vinblastine and irradiation in unresectable squamous cell lung cancer: failure patterns by cell type in RTOG 88-08/ECOG 4588, Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer, Management of unresectable stage III non-small-cell lung cancer. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . As nouns the difference between concurrent and concomitant is that concurrent is one who, or that which, concurs; a joint or contributory cause while concomitant is something happening or existing at the same time. In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. 16. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. No significant dose-response relationship was found in terms of LRC. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. We'll do our best to fix them. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 Table 1. Thanks for helping us catch any problems with articles on DeepDyve. Clin Oncol (R Coll Radiol) 2005;17:148-52. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. Select data courtesy of the U.S. National Library of Medicine. Look in other contemporaneous works to see whether that idea was common then. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. Bourhis J, Sire C, Graff P, Belderbos JSA, Senan S, et al to! Relationship was found in terms of LRC Oncol ( R Coll Radiol ) 2005 ; 17:148-52 a third chemotherapy to! For cancer patients to improve your online experience with TPF in concomitant vs concurrent chemotherapy with high-risk major SGCs did offer! A 30-min infusion on d 1 and 28 DeepDyve, PubMed, and Google Scholar seamlessly search keyword... 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